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2 edition of Molecular determinants of rotavirus virulence found in the catalog.

Molecular determinants of rotavirus virulence

Sanjay Kapoor

Molecular determinants of rotavirus virulence

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  • 22 Currently reading

Published by typescript in [s.l.] .
Written in English


Edition Notes

Thesis (Ph.D.)- University of Warwick, 1995.

StatementSanjay Kapoor.
ID Numbers
Open LibraryOL19085909M

The ability to replicate in the enteric tract directly correlates with virulence, as TGEVs with an exclusive respiratory tropism are attenuated. The tissue tropism is determined by spike (S) protein, although the molecular bases for enteric tropism remain to be fully atheizm.com: Carlos M. Sanchez, Alejandro Pascual-Iglesias, Isabel Sola, Sonia Zuñiga, Luis Enjuanes. For many pathogens, cell adhesion factors are critical virulence determinants. Enteropathogenic Yersinia species express the afimbrial adhesin YadA, the prototype of a class of homotrimeric outer membrane adhesins, which mediates adherence to host cells .


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Molecular determinants of rotavirus virulence by Sanjay Kapoor Download PDF EPUB FB2

The molecular basis of pathogenesis Molecular determinants of rotavirus virulence book vivo for a virulent mouse rotavirus (MRV) and a less virulent bovine rotavirus (BRV) were compared under in vit. Molecular determinants of rotavirus virulence Table 2.

Virulence of MRV and BRV in calf intestinal loops" Amount of fluid in jejunum (ml) MRV BRV Mid-jejunum Low-jejunum Mid-jejunum Low-jejunum 0 0 'The intestinal loops of calves were produced under anesthesia [21, Cited by: 2.

between rotavirus strains of different virulence, (iii) mapping virulence to rotavirus gene segments. The mouse model developed revealed that the outcome of rotavirus infection was influenced by viral dose and viral strain as well as by host age and host strain.

Homologous murine rotavirus strain was found to be most virulent. Jun 01,  · Molecular determinants of rotavirus virulence: localization of a potential virulence site in a murine rotavirus atheizm.com by: 2. Molecular determinants of rotavirus virulence. By Sanjay Kapoor. Get PDF (26 MB) Abstract.

Rotaviruses are the single most important etiological agent of\ud severe diarrhoea in infants and young children in both developed and\ud developing countries. The World Health Organisation has identified the\ud development of a rotavirus vaccine as a Author: Sanjay Kapoor.

Molecular determinants of rotavirus virulence was found to be different to the published rotavirus sequences including Molecular determinants of rotavirus virulence book recently published five murine rotavirus strains. The virulence mapping studies Molecular determinants of rotavirus virulence book in mice with some of the 22 reassortants obtained in the present study showed that gene 4 of the OSU and UKtc strains was Cited by: 1.

Author: Kapoor Molecular determinants of rotavirus virulence book. Search worldwide, life-sciences literature Search. Advanced Search.

E.g. "breast cancer" HER2 Smith JCited by: 1. Summary. The pathogenicity of rotaviruses depends on multiple viral and host factors. Evidence is presented for the involvement of a number of viral genes (coding for structural and non-structural proteins) in the ability of the virus to cause atheizm.com by: 6.

A genetic approach was used to define the molecular basis of these differences. The SA strain of rotavirus was more virulent than the NCDV strain when inoculated orally into newborn mice; the dose of SA required to cause diarrhea in 50% of infant mice was fold less than that required for atheizm.com by: Molecular basis of rotavirus virulence: Role of gene segment 4.

Bovine rotavirus NCDV and simian Molecular determinants of rotavirus virulence book SA exhibited markedly different patterns of gastrointestinal tract disease when inoculated orally into newborn mice.

A genetic approach was used to define the molecular basis of these differences. Molecular biology studies of rotavirus replication and pathogenesis have identified unique viral targets that might be useful in developing therapies for immunocompromised children with Cited by: Dec 05,  · We report the molecular characterization of a cloned rotavirus, PP-1, which was originally obtained from cattle and which had been biologically characterized in vivo in two target animal species, gnotobiotic pigs Molecular determinants of rotavirus virulence book calves.

In pigs, PP-1 caused severe clinical disease but in experimental calves it replicated atheizm.com by: The molecular basis of reovirus virulence: the role of the M2 gene. Article (PDF Available) in Journal of Experimental Medicine (4) · November with 60 Reads How we measure 'reads'.

Topics: 06V - Genetics, cytology, molecular biology, 06E - Medicine, 06M - Microbiology, Molecular determinants of rotavirus virulence [ Murine models, Gene mapping]Author: S Kapoor.

Viral determinants of rotavirus pathogenicity in pigs: production of reassortants by asynchronous coinfection. Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge, United Kingdom.

This article has been cited by other articles in atheizm.com by: Rotaviruses constitute the genus Rotavirus, one of the 15 genera of Reoviridae family which is subdivided into the sub-families of the Sedoreovirinae (genera Cardoreovirus, Mimoreovirus, Orbivirus, Phytoreovirus, Rotavirus, Seadornavirus) and the Spinareovirinae (genera Aquareovirus, Coltivirus, Cypovirus, Dinovernavirus, Fijivirus.

To further test our hypothesis that changes in NSP4 are associated with rotavirus virulence, the 10th genes from another pair of virulent and tissue culture-attenuated porcine (Gottfried strain) rotaviruses were atheizm.com by: Please be advised that we experienced an unexpected issue that occurred on Saturday and Sunday January 20th and 21st that caused the site to be down for an extended period of time and affected the ability of users to access content on Wiley Online Library.

Read the latest articles of Comparative Immunology, Microbiology and Infectious Diseases at atheizm.com, Elsevier’s leading platform of peer-reviewed scholarly literature. Evolution of Virulence in Eukaryotic Microbes addresses new developments in defining the molecular basis of virulence in eukaryotic pathogens.

By examining how pathogenic determinants have evolved in concert with their hosts, often overcoming innate and adaptive immune mechanisms, the book takes a fresh look at the selective processes that have. Main content area. Different virulence of porcine and porcine-like bovine rotavirus strains with genetically nearly identical genomes in piglets and calves.

Abstract. There are two candidate rotavirus vaccines that consist of a combination of four or more viral strains. Each of the two candidate vaccines is made by genetically reassorting one animal rotavirus strain (i.e., simian or bovine) with each of several human rotavirus strains.

virulence of rotavirus have implicated gene 4, In contrast to the genetic and molecular In this study, wefurther investigate genetic determinants of rotavirus virulence and HRRin the. Some of these mutations may be critical molecular determinants for RVA virulence and/or pathogenicity.

Introduction Group A rotavirus (RVA), a member of the Reoviridae family, is one of the major pathogens that causes severe and acute dehydrating diarrhea in young children and in a wide variety of domestic animals [ 1 - 3 ].Cited by: Pathogenesis of Rotavirus Gastroenteritis.

and virulence of viruses in different animal species by evaluating the molecular innate immune response to rotavirus (RVs). Feb 02,  · InDr. Jernigan joined the Influenza Division as Deputy Director.

Jernigan has authored peer-reviewed articles and book chapters on various emerging infectious diseases topics, and has supervised outbreak investigations of viral, bacterial, and fungal infections associated with emerging and antimicrobial-resistant pathogens.

Different virulence of porcine and porcine-like bovine rotavirus strains with genetically nearly identical genomes in piglets and calves and eight amino acid mutations in VP1-VP4 and NSP2. Some of these mutations may be critical molecular determinants for RVA virulence and/or pathogenicity.

library_books Different virulence of porcine. Molecular Medical Microbiology is the first book to synthesise the many new developments in both molecular and clinical research in a single comprehensive resource.

This timely and authoritative three-volume work is an invaluable reference source of medical bacteriology. Rotavirus Cross-Species Pathogenicity: Molecular Characterization of a Bovine Rotavirus Pathogenic for Pigs Article in Virology (1) · January with 59 Reads How we measure 'reads'. Abstract. Mixed infection of tissue culture cells is the primary means of studying genetic and nongenetic interactions between viral mutants.

The purpose of the mixed infection is to place two different viral genomes into the same cell, where interactions between the Cited by: 2. This concise volume reviews the most current and topical aspects of Pseudomonas molecular biology and genomics and is aimed at a readership of research scientists, graduate students and other specialists.

Renowned international authors have contributed chapters on diverse topics including taxonomy, genome diversity, oligonucleotide usage, polysaccharides, pathogenesis, virulence. Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence Issar Smith* TB Center, Public Health Research Institute, International Center for Public Health, genes that are or are potentially involved in virulence.

In the future, some of these genes and the proteins they encode, as there are many excellent books and Cited by: Aug 01,  · Molecular analysis of virulence determinants in clinical isolates suggests that strains are highly related to El Tor 01 strains.

Unlike other non-O 1 strains, strains carry multiple copies of the cholera toxin genetic element and also genes for the toxin-coregulated atheizm.com by: Rotavirus is a virus that infects the bowels, causing a severe inflammation of the stomach and bowels (known as gastroenteritis).

Rotavirus is the most common cause of severe diarrhea among infants and children throughout the world and causes the death of aboutchildren worldwide annually. The name rotavirus comes from the characteristic wheel-like appearance of the virus when viewed. NSP1, a non-structural protein encoded by rotavirus gene segment 5, has been suggested as a virulence determinant for rotavirus and to function as an antagonist of the interferon signalling pathway.

Although non-essential for rotavirus replication in cell culture, and is the least conserved in all rotavirus proteins, NSP1 from different rotavirus strains of different species has been.

Rotavirus is a genus of double-stranded RNA viruses in the family atheizm.comruses are the most common cause of diarrhoeal disease among infants and young children.

Nearly every child in the world is infected with a rotavirus at least once by the age of five. Immunity develops with each infection, so subsequent infections are less severe; adults are rarely atheizm.com: Reoviridae. A rotavirus has a characteristic wheel-like appearance when viewed by electron microscopy (the name rotavirus is derived from the Latin rota, meaning "wheel").

The virus is stable in the environment. The genome is composed of 11 segments of double-stranded RNA, which code for six structural and five nonstructural proteins. Because of the limitations in studying human rotavirus (HRV) pathogenesis and mucosal immunity in the natural host (infants and children), various animal models have been utilized to investigate rotavirus (RV) disease pathogenesis and immunity.

Mice and rabbits serve as useful models to evaluate and dissect immune responses to RV (see Chapter 9).Author: Linda J. Saif, Lucy A. Ward. Bouchard MJ, Lam DH, Racaniello VR () Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine.

J Virol – PubMed Google Scholar Bowles NE, Richardson PJ, Olsen EG, Archard LC () Detection of Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with Cited by: The role of specific genes and molecular determinants of neurotropism and viscerotropism has been defined only partially.

The availability of infectious clones and a small animal (hamster) model should allow dissection of virulence factors, which can then be tested in the more difficult monkey atheizm.com by:.

Get this from a library! Pdf and molecular aspects of bacterial virulence. [S Patrick; M J Larkin] -- The living mammalian host provides a unique environment for bacterial colonization. The authors of this work consider the strategies which have evolved in .To date there download pdf no rapid method to screen for highly pathogenic avian influenza strains that may be indicators of future pandemics.

We report here the first development of an oligonucleotide-based spectroscopic assay to rapidly and sensitively detect a N66S mutation in the gene coding for the PB1-F2 protein associated with increased virulence in highly pathogenic pandemic influenza viruses.

5 Cited by: Prevalence and Genetic Profiling of Virulence Ebook of Non-O Shiga Toxin-Producing Escherichia coli Isolated from Cattle, Beef, Aeromonas spp, rotavirus, parasites, and protozoans, following standard methods. and molecular characterization of the virulence genes.

The reasons for the low prevalence of STEC-associated diarrhea.